eTable 4. The effect of COCs on mortality^*2.

Cause of death	Never COC— number per 100 000 woman years	Ever COC— number per 100 000 woman years	Adjusted relative risk*1	95% CI
All cause mortality	417.45	365.51	0.88	0.82–0.93
All cancers	194.55	165.45	0.85	0.78–0.93
– colorectal	20.05	12.41	0.62	0.46–0.83
– hepatobiliary	3.12	2.03	0.65	0.30–1.39
– lung	26.08	31.70	1.22	0.96–1.53
– melanoma	2.67	1.95	0.73	0.33–1.61
– breast	43.91	39.41	0.90	0.74–1.08
– cervical	4.02	5.38	1.34	0.74–2.44
– endometrial	4.47	1.94	0.43	0.21–0.88
– ovarian	18.04	9.47	0.53	0.38–0.72
– gynecological cancers	26.51	16.80	0.63	0.49–0.82
All vascular diseases	115.18	99.15	0.86	0.77–0.96
– ischemic heart disease	57.41	42.85	0.75	0.63–0.88
– cerebrovascular disease	27.86	29.19	1.05	0.84–1.30
Violent death – suicide	12.86	19.20	1.49	1.09–2.05
	4.79	6.03	1.26	0.73–2.18

COC, combined oral contraceptives; CI, confidence interval;

^*1adjustied for age, parity, smoking, and socioeconomic status;

^*2data from Hannaford et al. 2010 (23)