FIGURE 7.
High nuclear expression of USP13 correlates with higher expression of Siah2 in melanoma tumors. A, melanoma tissue microarrays were stained with a mouse Siah2 antibody or a rabbit USP13 antibody, followed by HRP-conjugated anti-mouse or anti-rabbit antibody, respectively. The immunostaining was visualized with SG (black/blue), and the nuclei were counterstained with nuclear fast red (pink). B, chi-squared analysis of low (red) and high (green) nuclear USP13 (x axis) and nuclear Siah2 expression (y axis) in 371 melanoma histospots. USP13 and Siah2 are strongly co-expressed, χ2 = 53.8 (p < 0.0001).