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. 2011 Jun 2;286(31):27706–27717. doi: 10.1074/jbc.M110.213553

FIGURE 1.

FIGURE 1.

Schematic representation of glucose, aspartate, and alanine metabolism in Leishmania promastigotes. Pathways of glucose (black lines), aspartate (red lines), and alanine (blue lines) metabolism inferred from 13C-tracer experiments in this study. The numbered reactions and their subcellular localization are supported by previous biochemical studies and genome-wide annotations (38). Note that C4 dicarboxylic acids other than malate may be exported from the glycosomes and used to replenish TCA cycle reactions in the mitochondria. Abbreviations used are as follows: AcCoA, acetyl-CoA; Asp, aspartate; 1,3BPG, 1,3-bisphosphoglycerate; Cit, citrate; FBP, fructose-1,6-bisphosphatase; Fum, fumarate; G3P, glycerol 3-phosphate; G6P, glucose 6-phosphate; Gro, glycerol; F6P, fructose 6-phosphate; M6P, mannose 6-phosphate; Mal, malate; Mann, mannogen oligomers with n mannose residues; OAA, oxaloacetic acid; OAc, acetate; 3PG, 3-phosphoglycerate; Pyr, pyruvate; R5P, ribose 5-phosphate; SCoA, succinyl-CoA; Suc, succinate. Enzyme steps are as follows; 1, hexokinase; 2, glucose-6-phosphate isomerase; 3, phosphofructokinase; 4, aldolase; 5, triose-phosphate isomerase; 6, glyceraldehyde-3-phosphate dehydrogenase (glycosome and cytosolic isoforms); 7, phosphoglycerate kinase (glycosome and cytosolic isoforms); 8, phosphoglycerate mutase; 9, enolase, 10, pyruvate kinase; 11, pyruvate dikinase; 12, phosphoenolpyruvate carboxykinase (PEPCK); 13, malate dehydrogenase, 14, fumarase; 15, NADH-dependent fumarate reductase; 16, NADH-dependent glycerol-3-phosphate dehydrogenase; 17, malic enzyme; 18, alanine aminotransferase; 19, aspartate aminotransferase; 20, malate dehydrogenase (cytosolic isoform); 21, pyruvate dehydrogenase complex; 22, citrate synthase; 23, aconitase; 24, NADPH-dependent isocitrate dehydrogenase; 25, α-ketoglutarate dehydrogenase; 26, succinyl-CoA synthetase; 27, succinate dehydrogenase; 28, fumarase; 29, malate dehydrogenase; 30, acetate:succinyl-CoA-transferase; 31, NADPH-dependent glutamate dehydrogenase; 32, mannose-6-phosphate isomerase; 33, mannose-6-phosphate mutase; 34, GDP-Man pyrophosphorylase.