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. 2011 Aug;138(2):179–194. doi: 10.1085/jgp.201110623

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© 2011 Talukder and Wollmuth

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Figure 7. — Effects of the intrasubunit GluN1 or GluN2A cross-links on the kinetic mechanism of NMDA receptor activation. (A) Sequential-state model (Kussius and Popescu, 2009) of NMDA receptor activation with the rate constants (s⁻¹) of transitions averaged from fits of individual single-channel recordings. Significant differences (P < 0.05) relative to WT are indicated with colored rate constants. Significant differences (P < 0.05) between GluN1(C,C)/GluN2A and GluN1/GluN2A(C,C) are indicated with asterisks. (B) Mean fold change (±SEM) in rate constants relative to GluN1/GluN2A. The left and right axes show the reverse and forward rate constants, respectively. Significant differences (P < 0.05) relative to WT and between GluN1(C,C)/GluN2A and GluN1/GluN2A(C,C) are indicated with filled bars and asterisks, respectively. (C) Free energy landscape plotted with respect to C₂. The off-pathway steps to and from C₄ and C₅ are excluded. The three traces are horizontally offset for clarity.