Figure 4.

DNA methylation and H3K4me3/H3K27me3 are mutually exclusive on the majority of genomic locations. (A) Distribution of DNA methylation over boundaries of H3K4me3 peaks. DNA methylation is excluded from the bulk of genomic H3K4me3 sites even though above average DNA methylation can be observed on sequences flanking the H3K4me3 peaks. (B) Genomic example of the exclusion of DNA methylation and H3K4me3. (C) Broad H3K27me3 domains are mostly DNA methylation-free, even though smaller H3K27me3 peaks can be methylated. (D) hoxb cluster as an example of the mutual exclusion of H3K27me3 and DNA methylation. (E) H3K4me3 and H3K27me3 peaks are enriched for CpG dinucleotides but depleted of DNA methylation.