TABLE II.

Outcome data from studies in patients receiving combined chemoradiotherapy

Reference	Weight loss during chemoradiotherapy		Deviation from treatment regimen		Length of feeding tube dependency		Stenosis or stricture
	Intervention	Control	Intervention	Control	Intervention	Control	Intervention	Control
Studies with a control group
Bahl et al., 20048	Mean: 18%	∼14%	57%	71%	Mean: 145 days	Mean: 116 daysa	nr	nr
Allen et al., 20079	Median: 3.8%	7.9%	nr	nr	14 patients required feeding tube for >3 months		7 patients (32%)
Studies without a control group
Wiggenraad et al., 200710	Mean: 2.8% (2.3 kg)	—	28%	—	Median: 178 days	—	nr	—
Nguyen et al., 200611	Mean: 8.5 kg Median: 8 kg	—	nr	—	Mean: 8 months Median: 5 months	—	nr	—
Goguen et al., 200612	Median: 9.6 kg (13% of body weight)	—	nr	—	Median: 21 weeks	—	8 patients (14%)	—
Nguyen et al., 200413	Median: 8 kg	—	20%	—	22 (40%) required feeding tube for >3 months	—	3 patients (5.4%)	—
Marcy et al., 20006	Mean gain: 2.5 kg	—	nr	—	Up to 605 days	—	nr	—

^aAmong those who had a feeding tube inserted because of toxicity during treatment.

Intervention = prophylactic feeding tube; Control = feeding tube inserted during treatment, or no feeding tube needed; nr = not reported.