Table 1. Top downregulated genes common to both 786-O and SKRC-10 cells upon γ-secretase inhibition when compared to vehicle treatment for 24 hours as evaluated from microarray data.

	786-O		SKRC-10
Gene name	Mean ratio	Z	Mean ratio	Z
HES1	−1.44	−4.80	−2.98	−8.54
IL7R	−0.77	−2.57	−1.74	−5.02
LOC284422	−2.10	−6.96	−1.48	−4.30
CXCL12	−1.32	−4.38	−1.31	−3.80
CXCR7	−1.03	−3.44	−1.30	−3.78
SNF1LK	−0.71	−2.37	−1.29	−3.74
GPR56	−0.82	−2.73	−1.25	−3.63
MAOB	−1.15	−3.84	−1.22	−3.55
SERPINE1	−0.96	−3.19	−1.21	−3.53
SEMA3F	−1.11	−3.69	−1.19	−3.47
KRTAP9-4	−1.07	−3.59	−1.16	−3.38
LPHN1	−1.37	−4.58	−1.14	−3.34
HSF2BP	−0.71	−2.38	−1.13	−3.29
CLTCL1	−1.05	−3.49	−1.07	−3.13
MN1	−0.93	−3.10	−1.07	−3.13
GALNT2	−0.82	−2.76	−0.91	−2.68
LRP4	−0.71	−2.40	−0.90	−2.63
CHAC1	−0.70	−2.34	−0.84	−2.47
FAM20C	−0.63	−2.13	−0.80	−2.35
INHBA	−1.36	−4.54	−0.79	−2.32
SR-A1	−0.61	−2.06	−0.74	−2.18
SKIL	−0.68	−2.27	−0.69	−2.05

Genes in bold represents previously described TGF-β signaling target genes. Data represents mean log₂ ratios (DAPT/DMSO) and Z-scores of three separate experiments. The genes are sorted according to the Z-scores of SKRC-10.