Table 1. Top downregulated genes common to both 786-O and SKRC-10 cells upon γ-secretase inhibition when compared to vehicle treatment for 24 hours as evaluated from microarray data.
786-O | SKRC-10 | |||
Gene name | Mean ratio | Z | Mean ratio | Z |
HES1 | −1.44 | −4.80 | −2.98 | −8.54 |
IL7R | −0.77 | −2.57 | −1.74 | −5.02 |
LOC284422 | −2.10 | −6.96 | −1.48 | −4.30 |
CXCL12 | −1.32 | −4.38 | −1.31 | −3.80 |
CXCR7 | −1.03 | −3.44 | −1.30 | −3.78 |
SNF1LK | −0.71 | −2.37 | −1.29 | −3.74 |
GPR56 | −0.82 | −2.73 | −1.25 | −3.63 |
MAOB | −1.15 | −3.84 | −1.22 | −3.55 |
SERPINE1 | −0.96 | −3.19 | −1.21 | −3.53 |
SEMA3F | −1.11 | −3.69 | −1.19 | −3.47 |
KRTAP9-4 | −1.07 | −3.59 | −1.16 | −3.38 |
LPHN1 | −1.37 | −4.58 | −1.14 | −3.34 |
HSF2BP | −0.71 | −2.38 | −1.13 | −3.29 |
CLTCL1 | −1.05 | −3.49 | −1.07 | −3.13 |
MN1 | −0.93 | −3.10 | −1.07 | −3.13 |
GALNT2 | −0.82 | −2.76 | −0.91 | −2.68 |
LRP4 | −0.71 | −2.40 | −0.90 | −2.63 |
CHAC1 | −0.70 | −2.34 | −0.84 | −2.47 |
FAM20C | −0.63 | −2.13 | −0.80 | −2.35 |
INHBA | −1.36 | −4.54 | −0.79 | −2.32 |
SR-A1 | −0.61 | −2.06 | −0.74 | −2.18 |
SKIL | −0.68 | −2.27 | −0.69 | −2.05 |
Genes in bold represents previously described TGF-β signaling target genes. Data represents mean log2 ratios (DAPT/DMSO) and Z-scores of three separate experiments. The genes are sorted according to the Z-scores of SKRC-10.