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. 2011 Aug 3;6(8):e23262. doi: 10.1371/journal.pone.0023262

Figure 7. The speculated role of TRAPPC4-ERK2 interaction in CRC.

Figure 7

Extracellular signals, such as PDGF, activate ERK cascades(RAS/RAF/MER/ERK) through receptor tyrosine kinases (RTKs) and utimately regulate cell proliferation and apoptosis. TRAPPC4 binds and activates ERK1/2 as well as participates in the nuclear transport of pERK1/2. When TRAPPC4 is depleted, less ERK1/2 is phosphorylated, and relatively more pERK1/2 remains in the cytoplasm, which leads to suppression of cell proliferation and apoptosis. When TRAPPC4 is overexpressed, more ERK1/2 is activated, and even more is transported into the nucleus, finally leading to increased cell growth.