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. 2011 Aug 3;6(8):e23311. doi: 10.1371/journal.pone.0023311

Table 3. The tumor formation of distinct typed cells in nude mice.

Cell subpopulations Tumor incidence Tumor diameter Metastasis incidence
SP-HCCs (1×107) 4/4 +++ 4/4
SP-HCCs (1×106) 4/4 ++ 4/4
SP-HCCs (1×105) 4/4 ++ 4/4
SP-HCCs (1×104) 4/4 + 4/4
NSP-HCCs (1×107)a 4/4 ++ 0/4
NSP-HCCs (1×106)b 3/4 + 0/4
NSP-HCCs (1×105)c 2/4 + 0/4
NSP-HCCs (1×104)d 0/4 0/4

“Tumor incidence” indicates the average incidence of tumors in each mice (4 mice in each group, 4/4 means 4 tumors in 4 injection sites). “Tumor diameter” refers to the average diameter of tumors in each group (−, no macroscopic tumor; +, <0.2 cm; ++, 0.2–0.5 cm; +++, >0.5 cm). “Metastasis incidence” means the average incidence of the liver neoplasia appeared in each group (4/4 means 4 liver neoplasias found in 4 mice). All results were independently viewed by three different researchers.

a–d

NSP-HCCs vs. SP-HCCs (the same number), P<0.01.