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A. Sequence information on LRP5 around the new deletion. B. Functional evaluation of canonical Wnt signalling in Saos-2 cells expressing WT or mutant LRP5. Fold induction of luciferase reporter activity in cells is normalized to the fold induction in cells expressing only the Wnt1-V5 expression construct. Bars represent average values ± SD. *: p-value < 0.05.
