Table 2.
Effect of DOC and CGA in diet on tumor and cancer development
| Added to AIN93 diet | Months on diet | Number of mice | Mice with tumors (adenomas + cancers) | Mice with cancer | Number of tumors (tumor burden**) | Number of cancers (cancer burden***) |
|---|---|---|---|---|---|---|
| DOC | 8 | 12 | 12 (100%) | 6 (50%) | 16 (1.3) | 7 (0.6) |
| 10 | 6 | 5 (83%) | 4 (67%) | 13 (2.2) | 8 (1.3) | |
| Total 18 | Total 17 (94%) | Total 10 (56%) | Total 29 (1.6) | Total 15 (0.83) | ||
| DOC + CGA | 8 | 6 | 4 (67%) | 1 (17%) | 5 (0.8) | 1 (0.2) |
| 10 | 5 | 3 (60%) | 1 (20%) | 5 (1.0) | 1 (0.2) | |
| Total 11 | Total 7 (64%) | Total 2 (18%) | Total 10 (0.9) | Total 2 (0.2) | ||
| CGA | 8 | 6 | 0 | 0 | 0 | 0 |
| 10 | 6 | 0 | 0 | 0 | 0 | |
| Total 12 | Total 0 | Total 0 | Total 0 | Total 0 | ||
| None | 8 | 6 | 0 | 0 | 0 | 0 |
| 10 | 6 | 0 | 0 | 0 | 0 | |
| Total 12 | Total 0 | Total 0 | Total 0 | Total 0 |
DOC deoxycholate, CGA chlorogenic acid
** Tumor burden is the ratio of the number of tumors observed to the number of mice
*** Cancer burden is the ratio of the number of cancers observed to the number of mice