Table 3.
Sequences of the scFv CDRs specific to the extra-domain A of fibronectin
scFv | VH chain (DP-47) | VL chain | ||||
31–33a | 52 | 95–100a | 31–32a | 91–96a | Germline | |
scFv(F10) | S Y A | N | YIRTKD | S Y Y | ITGYPV | DPL-16 |
scFv(2H7) | K F K | N | YIRTKD | S Y Y | ITGYPV | DPL-16 |
scFv(F8) | L F T | S | STHLYL | M P F | MRGRPP | DPK-22 |
Linkers | ||||||
CRAb (10 aa linker) | GGG GSG GGG S | |||||
CRAb (18 aa linker) | GSS SGS DGK ASG GSA SGG |