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. 2011 May 1;3(3):273–288. doi: 10.4161/mabs.3.3.15188

Figure 2.

Figure 2

Binding activities of EI-04 BsAb and its parental anti-EGFR and anti-IGF-1R mAbs. (A and B) Biacore surface plasmon resonance sensorgrams of soluble EGFR ectodomain (0–30 nM) to chip-captured EI-04 (A) and anti-EGFR mAb M60-A02 (B). (C) Octet Red biolayer interferometry-based equilibrium analysis for soluble IGF-1R ectodomain binding to tip-bound EI-04 and anti-IGF-1R mAb C06. (D) Biacore surface plasmon resonance sensorgrams demonstrating serial binding of IGF-1R ectodomain and Fc-tagged EGFR ectodomain to EI-04.