Table 6.
Selected antibody mimetics and their key patents
| Company | Scaffold protein | Technology name | Size | Example drug | Key technology patent |
| Molecular Partners | Ankyrin repeat proteins | “DARPins” | 10–19 kDa | MP0112 (Anti-VEGF) | US7417130 |
| Borean Pharma | C-Type Lectins | “Tetranectins“ | US2004132094 | ||
| Affibody | A-domain proteins of S. aureus | “Affibodies” | 6 kDa | ABY-025 (Anti-HER2) | US5831012 |
| BioRexis/Pfizer | Transferrin | “Transbodies” | US2004023334 | ||
| Pieris Proteolab | Lipocalins | “Anticalin” | 20 kDa | PRS-050 | US7250297 |
| Adnexus/Bristol Myers Squibb | 10th type III domain of fibronectin | “AdNectins” (Monobodies) | 10 kDa | Angiocept (CT-322; anti-VEGFR2) | US6818418 |
| Dyax | Kunitz domain protease inhibitors | 6 kD | Ecallantide (anti-Kallikrein) | US2004209243 | |
| Scil Proteins GmbH | Ubiquitin derived binders | “Affilin” | 10 kDa | SPVF2801-30 (anti-EDB) | US7838629 |
| Gamma Crystallin derived binders | 20 kDa | ||||
| Selecore/Nascacell | Cysteine knots or knottins | “Microbodies“ | US7186524 | ||
| General Hospital/Genetics Institute | Thioredoxin A scaffold | “Peptide aptamers” | US6004746 | ||
| Archemix | Nucleic acid aptamers | Pegaptanib (anti-VEGF); ARC1779 (anti-vWillebrandt) | US5475096 | ||
| Catalyst Biosciences | Target specific proteases obtained by directed evolution | “Alterases” | US2004146938 | ||
| Mosbach/Lund University | Artificial Antibodies produced by molecular imprinting of polymers | “Plastic antibodies” | US2004157209 | ||
| Phylogica | Peptide libraries from bacterial genomes | “Phylomers“ | US6994982 | ||
| NextBiomed | SH-3 domains | US6794144 | |||
| Gliknik | Antibody-mimetics | “Stradobody” | US2010239633 | ||
| Avidia/Amgen | “A domains” of membrane receptors stabilized by disulfide bonds and Ca2+ | “Avimers“ “Maxibodies“ | 9–18 kDa | US7803907 | |
| Evogenix/Cephalon | CTLA4-based compounds | “Evibody” | US7166697 | ||
| Covagen | Fyn SH3 | “Fynomers“ | 7 kDa | US2010119446 |
CTLA, Cytotoxic T-Lymphocyte Antigen; EDB, extracellular domain B; HER, human epidermal growth factor receptor; kDa, kilo Dalton; VEGF, vascular endothelial growth factor.