Table 5. Binding affinity of CPTI peptides for cis-parinaroyl-CoA and palmitoyl-CoA.
Values represent the mean value ± the standard error, n = 5.
| Cpn-CoA Kd (nM) |
Displacement KI (nM) |
Quenching Kd (nM) |
|
|---|---|---|---|
| CPTI WT | 9 ± 1 | 2.7 ± 0.5 | 5 ± 1 |
| W391A | 52 ± 8 | 7 ± 1 | 9 ± 1 |
| W452A | 67 ± 10 | 17 ± 3 | 16 ± 2 |