Table III.

Odds ratios and p-values for active asthma from longitudinal models over 1, 2, 3 and 5 years, for individual cytokines (Unadjusted) and for Th2 cytokines adjusted for IFN-γ levels (Adjusted), at 3 and 12 months, for all subjects and stratified by specific IgE detectability through age 5.^*

		Active asthma, Ages 1-2-3-5 years
		All subjects		No detectable specific IgE through age 5		Any detectable specific IgE through age 5
		OR	p-val	OR	p-val	OR	p-val
3 Month Cytokines
Unadjusted
	IL-4	1.3	0.272	0.8	0.336	1.4	0.206
	IL-5**	1.1	0.793	0.4	0.185	1.6	0.299
	IL-13	1.9	0.004	2.3	0.008	1.5	0.153
	IFN-γ	0.8	0.145	0.7	0.268	0.7	0.259
Adjusted
	IL-4	1.6	0.071	0.8	0.605	1.8	0.047
	IFN-γ	0.6	0.028	0.8	0.567	0.6	0.037
	IL-5**	1.2	0.575	0.4	0.241	1.7	0.205
	IFN-γ	0.7	0.127	0.8	0.373	0.7	0.201
	IL-13	2.6	<0.001	3.5	<0.001	1.9	0.038
	IFN-γ	0.5	0.001	0.4	0.009	0.5	0.023
12 Month Cytokines
Unadjusted
	IL-4	1.2	0.302	1.1	0.669	1.2	0.484
	IL-5	1.0	0.844	0.9	0.802	0.9	0.717
	IL-13	1.0	0.884	1.0	0.998	1.0	0.966
	IFN-γ	0.9	0.440	0.7	0.165	1.1	0.814
Adjusted
	IL-4	1.3	0.180	1.3	0.370	1.2	0.490
	IFN-γ	0.8	0.226	0.6	0.099	1.0	0.945
	IL-5	1.0	0.939	1.0	0.866	0.9	0.636
	IFN-γ	0.9	0.445	0.7	0.170	1.1	0.676
	IL-13	1.1	0.620	1.3	0.458	1.0	0.882
	IFN-γ	0.8	0.375	0.6	0.126	1.1	0.745

^*All subjects: N_{3 Months} = 307–310; N_{12 Months} = 309–316; Subjects with no detectable specific IgE: N_{3 Months} = 153–155; N_{12 Months} = 154–159 Subjects with detectable specific IgE: N_{3 Months} = 144–145; N_{12 Months} = 155–157

^**Dichotomized: Detectable/Undetectable.