Table 3.
Unadjusted and Adjusted Hazard Ratios (HR) of Knee Outcomes, by Biomarker.
| Predictor | Outcome | # Knees at Risk | # Knees with Outcome | Unadjusted HR | 95% CI | Wald Chi-square P-value | Adjusted HR† | 95% CI | Wald Chi-square P-value |
|---|---|---|---|---|---|---|---|---|---|
| ln(COMP) | Knee OA (K-L)* | 542 | 110 | 1.73 | 1.18-2.53 | <0.01 | 1.39 | 0.90-2.13 | 0.13 |
| Knee OST* | 353 | 94 | 1.97 | 1.32-2.93 | <0.01 | 2.16 | 1.39-3.37 | <0.01 | |
| Knee JSN* | 446 | 102 | 2.24 | 1.46-3.45 | <0.01 | 1.82 | 1.15-2.89 | 0.01 | |
|
| |||||||||
| ln (HA) | Knee OA (K-L) | 542 | 110 | 1.33 | 1.09-1.62 | <0.01 | 1.12 | 0.90-1.40 | 0.30 |
| Knee OST | 353 | 94 | 1.20 | 0.97-1.48 | 0.09 | 0.91 | 0.70-1.19 | 0.49 | |
| Knee JSN | 446 | 102 | 1.51 | 1.22-1.87 | <0.01 | 1.46 | 1.14-1.87 | <0.01 | |
|
| |||||||||
| ln(hsCRP) | Knee OA (K-L) | 542 | 110 | 1.09 | 0.95-1.24 | 0.22 | 0.99 | 0.84-1.16 | 0.89 |
| Knee OST | 353 | 94 | 0.95 | 0.82-1.09 | 0.57 | 0.94 | 0.79-1.12 | 0.46 | |
| Knee JSN | 446 | 102 | 1.16 | 1.01-1.34 | 0.04 | 1.10 | 0.93-1.30 | 0.27 | |
|
| |||||||||
| ln (KS) | Knee OA (K-L) | 542 | 110 | 1.24 | 0.76-2.04 | 0.39 | 1.16 | 0.66-2.03 | 0.61 |
| Knee OST | 353 | 94 | 1.89 | 1.03-3.47 | 0.04 | 1.56 | 0.82-2.95 | 0.17 | |
| Knee JSN | 446 | 102 | 1.21 | 0.70-2.11 | 0.50 | 1.15 | 0.64-2.07 | 0.64 | |
*
OA=osteoarthritis, K-L=Kellgren-Lawrence, OST=osteophyte formation, JSN=joint space narrowing
†
Adjusted for age, body mass index, race, gender, and osteoarthritis in contralateral knee at baseline.