Table 4.

Adjusted Hazard Ratios (HR) of Knee Outcomes, by Biomarker, Stratified by Chronic Knee Symptoms at Baseline.

		Chronic Knee Symptoms				No Chronic Knee Symptoms
Biomarker	Knee Outcome	# Knees at Risk	# Knees with Outcome	Adjusted HR†	95% CI	# Knees at Risk	# Knees with Outcome	Adjusted HR†	95% CI	P-value of Interaction‡
ln (COMP)	KL score*	166	46	2.04	1.05-3.99	374	64	1.37	0.77-2.45	0.10
	OST*	97	33	4.14	1.84-9.30	254	61	1.79	0.99-3.20	0.80
	JSN*	130	35	1.99	0.90-4.38	314	66	1.90	1.02-3.52	0.55
ln(HA)	KL score	166	46	1.14	0.79-1.66	374	64	1.01	0.76-1.33	0.16
	OST	97	33	1.11	0.67-1.87	254	61	0.85	0.62-1.16	0.38
	JSN	130	35	1.97	1.27-3.05	314	66	1.36	1.00-1.83	0.76
ln(hsCRP)	KL score	166	46	1.12	0.86-1.46	374	64	0.99	0.79-1.23	0.09
	OST	97	33	1.03	0.76-1.41	254	61	0.88	0.71-1.09	0.39
	JSN	130	35	1.05	0.77-1.45	314	66	1.11	0.91-1.36	0.69
ln (KS)	KL score	166	46	1.59	0.66-3.84	374	64	0.89	0.41-1.92	0.11
	OST	97	33	3.47	1.15-10.45	254	61	1.19	0.52-2.72	0.43
	JSN	130	35	2.41	0.85-6.80	314	66	0.83	0.39-1.78	0.77

^*K-L=Kellgren-Lawrence, OST=osteophyte formation, JSN=joint space narrowing

^†Adjusted for age, BMI, race, gender, and osteoarthritis in contralateral knee at baseline.

^‡Interaction of ln(biomarker) and knee symptoms variable.