. Author manuscript; available in PMC: 2012 Nov 15.

Published in final edited form as: J Neurosci Methods. 2011 Mar 8;202(2):158–164. doi: 10.1016/j.jneumeth.2011.03.001

Table I.

Correlations between Demon Voltammetry measures and Michaelis-Menten parameters

Measure	Baseline V_max	Apparent K_m	[DA_p]
tau	−0.4414	^*** 0.9989	^* −0.7311
FWHH	−0.5233	^*** 0.9976	^* −0.7090
Half-life	−0.4407	^*** 0.9989	^* −0.7307
T₂₀	−0.5200	^*** 0.9988	^* −0.7324
T₈₀	−0.5420	^*** 0.9675	−0.7002
Slope	^* 0.6718	^*** 0.9901	^* −0.7991
Peak height	0.2657	−0.55772	^*** 0.9535
[DA_c]	0.5262	−0.56369	^*** 0.9613
AUC	0.01692	0.6706	−0.1373

Tau, full width at half height (FWHH), half-life, T₂₀, and T₈₀, were positively correlated with K_m, suggesting that these are accurate measures of DA uptake. Slope was also correlated with K_m but was unable to detect uptake changes at the lowest cocaine concentrations (see figure 5). Peak Height and [DA_c] were positively correlated with [DA_p] suggesting that these are accurate measures of release. Area under the curve (AUC) was not significantly correlated with either K_m or [DA_p].

(P ≤ 0.05);

^***

(P ≤ 0.0001).