Table 2.

Frequency of HLA-class II alleles in AFA positive AA patients with SSc compared to ethnically matched AFA negative patients and unaffected controls

HLA class- II alleles	AFA positive (n=50)	AFA negative (n=221)	Unaffected controls (n=329)	AFA positive AA patients vs. unaffected AA controls			AFA positive vs. negative AA patients
				Odds ratio (95%CI)	p-value	p-value*	Odds ratio(95%CI)	p-value	p-value*
DRB1*08:04	47.6%	14.9%	6.4%	13.20 (6.24,27.94)	< 0.001	< 0.001	5.21 (2.44,11.09)	<0.001	<0.001
DQA1*04:01	33.3%	17.5%	20.6%	1.95 (0.97,3.90)	0.060	NS**	2.37 (1.10,5.09)	0.026	NS**
DQB1*03:01	69.1%	56.5%	39.0%	3.49 (1.75,6.95)	<0.001	0.005	1.72 (0.83, 3.56)	0.153	NS**
DPB1*01:01	80%	50.8%	47.8%	4.38 (1.08,25.21)	0.019	NS**	4.12 (1.07,15.89)	0.041	NS**
DRB1*11:01	0%	16.9%	11.8%	N/A†	0.019	NS**	N/A†	0.004	NS**

^*corrected p-value,

^**NS: not significant,

^†N/A: Not applicable.