High and low antibody responders to influenza vaccination were evaluated for the presence of flares using the SELENA-SLEDAI method (24, 25) for all individuals at six and twelve weeks post vaccination. Shown is the total number of individuals experiencing no flare (white bars), mild/moderate flare (dotted bars), or severe flares (gray bar) (A), the vaccine responsiveness (high or low) of individuals with a flare at 6 weeks post vaccination (B), and the vaccine responsiveness (high or low) of individuals with a flare at 12 weeks post vaccination (C).