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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Clin Cancer Res. 2011 Jun 20;17(15):5038–5047. doi: 10.1158/1078-0432.CCR-11-0358

Figure 1. The effects of selumetinib and 5-FU on tumor cell radiosensitivity.

Figure 1

Cell lines HT29 (A), HCT116 (B), and MiaPaCa-2 (C) were exposed to 15μM 5-FU (or vehicle) for 18 hours and selumetinib (or vehicle) for 2 hours and irradiated with graded doses of X-rays. Colony forming efficiency was determined 10–12 days later and survival curves generated after normalizing for cell killing by selumetinib, 5-FU or selumetinib + 5FU in the absence of IR. The data represent the mean of three independent experiments. Points, mean; bars, standard error; DMF, dose modifying factor; toxicity, mean plating efficiency at 0 Gy.