Fig. 1.

Effects of paroxetine on uptake over a range of 5-HT concentrations in SERT wildtype and knockout synaptosomes. Paroxetine decreases 5-HT clearance in SERT wildtype but not knockout mice at concentrations at 500 nM 5-HT and lower. The effect of 1 μM paroxetine was significant in SERT wildtype but not knockout synaptosomes as determined by repeated measures two-way ANOVA (p for factor paroxetine, genotype, interaction) at (A) 50 nM; p = 0.0121; 0.812; 0.005, (B) 100 nM; p = 0.003; 0.750; 0.001, (C) 200 nM; p = 0.0003; 0.957; 0.005, (D) 300 nM; p = 0.0574; 0.836; 0.028, (E) 500 nM; p = 0.0261; 0.638; 0.039, but not (F) 1 μM; p = 0.657; 0.841; 0.203 (n = 5 per [5-HT]). *p < 0.05, **p < 0.01, ***p < 0.001 as determined by post hoc Bonferroni posttests. Note that the Y-axes differ in each case so that the treatment differences are clearly represented.