Figure 4.

Treating disseminated ovarian SK-OV-3 tumors with HER2-Affitoxin.

Mice bearing peritoneal SK-OV-3-luc-D3 tumors were treated with vehicle (control) or received 6 doses of HER2-Affitoxin (0.25 mg/kg) every third day, as indicated by arrows. A, BLI images taken 11 days after the last dose of HER2-Affitoxin was injected. B, Changes in mean bioluminescence intensity during the course of the experiment (arrows indicate HER2-Affitoxin injection time points and asterisks represent the statistical significance between groups; p < 0.05, as determined by t-student test). C, Average and signal distributions in control- and HER2-Affitoxin-treated groups 11 days after the last dose was injected (p value was determined by one-tailed t-student test). Control and treated groups of mice were injected IP with D-Luciferin solution (75 mg/kg). Images were acquired using IVIS Lumina imaging systems 8–10 minutes after D-Luciferin administration.