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. Author manuscript; available in PMC: 2012 Jul 1.

Published in final edited form as: Alzheimers Dement. 2011 Jul;7(4):402–411. doi: 10.1016/j.jalz.2010.12.014

A, Box plots showing distribution of concentrations for total tau (T-tau) for each of the three treatment groups. The “boxes” indicate the range of values between the 25^th and 75^th percentiles. “Whiskers” indicate the range of values that did not lie outside the interquartile range (IQR, between 25^th and 75^th percentile) by more than 1.5 X the IQR. Although statistically anomalous, the apparent outliers were probably individuals whose elevated tau concentration was a realistic signal of neurodegenerative illness. All values were considered in the statistical analyses.

B, Box plots showing distributions of concentrations for CSF Aβ_1–42 by treatment assignment. The meaning of the outlying values here is less clear. All values were again considered in the analyses.

C, Box plots showing distribution by treatment assignment for the ratio of T-tau to Aβ_1–42 concentrations. The ratios for celecoxib- and placebo-assigned participants were typical of other cognitively normal elderly subjects analyzed in the same laboratory [19]. Ratios for naproxen-assigned participants were reduced, compared to placebo, by 40%.

A, Box plots showing distribution of concentrations for total tau (T-tau) for each of the three treatment groups. The “boxes” indicate the range of values between the 25^th and 75^th percentiles. “Whiskers” indicate the range of values that did not lie outside the interquartile range (IQR, between 25^th and 75^th percentile) by more than 1.5 X the IQR. Although statistically anomalous, the apparent outliers were probably individuals whose elevated tau concentration was a realistic signal of neurodegenerative illness. All values were considered in the statistical analyses.

B, Box plots showing distributions of concentrations for CSF Aβ_1–42 by treatment assignment. The meaning of the outlying values here is less clear. All values were again considered in the analyses.

C, Box plots showing distribution by treatment assignment for the ratio of T-tau to Aβ_1–42 concentrations. The ratios for celecoxib- and placebo-assigned participants were typical of other cognitively normal elderly subjects analyzed in the same laboratory [19]. Ratios for naproxen-assigned participants were reduced, compared to placebo, by 40%.