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. Author manuscript; available in PMC: 2012 Aug 10.
Published in final edited form as: Toxicol Lett. 2011 Apr 21;205(1):1–7. doi: 10.1016/j.toxlet.2011.04.011

Figure 3.

Figure 3

ACR intoxication does not upregulate phase II detoxifying enzymes or antioxidant proteins in subcellular fractions of brain or liver. (A). Representative immunoblots are presented for Nrf2, Keap1, the cytoprotective proteins in brain and subcellular fractions from control and ACR-intoxicated animals. Also shown is the loading control, GAPDH. Proteins were loaded on gels at 25 μg per lane. CON = control; IP = intraperitoneal injection, 50 mg/kg/d × 10 days; ORAL = oral intoxication; 21 mg/kg/d × 38 days. (B). Relative immunoblot intensities for individual subcellular fractions of brain and liver are presented. Immunoblots for brain and liver cytosolic compartments (BC, LC respectively) are not shown, but were not altered by ACR intoxication.