Effect of ZnR on fear extinction using a paradigm consisting of one CS presentation during extinction retrieval. ZnR beginning 21 d before conditioning (Cond) rescued impaired extinction learning and retrieval in S1 mice and facilitated extinction learning in B6 mice, relative to control diet (Ctl) (n = 6 per group). Data are presented as means ± SEM. *p < 0.05, S1 control diet versus B6 control diet; #p < 0.05, S1 control diet versus S1 ZnR; †p < 0.05, B6 ZnR versus S1 control diet; §p < 0.05, B6 control diet versus B6 ZnR.