. 2010 Oct 13;30(41):13586–13596. doi: 10.1523/JNEUROSCI.0849-10.2010

Table 3.

IEG expression after (1 CS presentation) extinction retrieval in mice fed control or ZnR diets 3 weeks prior to conditioning

Region (distance from bregma)	c-Fos					Zif268
	S1		B6		Strain–diet interaction	S1		B6		Strain–diet interaction
	Ctl	ZnR	Ctl	ZnR	Strain–diet interaction	Ctl	ZnR	Ctl	ZnR	Strain–diet interaction
Cortical regions
M1, 1.78 mm	0.7 ± 0.2	0.6 ± 0.3	0.6 ± 0.2	0.8 ± 0.3	F_{(1, 20)} = 0.44, p = 0.51	14.0 ± 0.6	13.6 ± 0.5	14.2 ± 0.9	14.3 ± 1.0	F_{(1, 20)} = 0.10, p = 0.75
M2, 1.78 mm	1.8 ± 0.9	1.8 ± 0.6	1.4 ± 0.2	1.5 ± 0.3	F_{(1, 20)} = 0.01, p = 0.94	17.3 ± 0.9	18.3 ± 1.0	17.3 ± 1.1	17.8 ± 0.7	F_{(1, 20)} = 0.10, p = 0.76
Cg1, 1.78 mm	1.7 ± 0.2	2.2 ± 0.5	2.4 ± 0.5	2.6 ± 1.0	F_{(1, 20)} = 0.08, p = 0.78	17.9 ± 1.4	17.7 ± 0.4	18.0 ± 0.4	18.8 ± 0.9	F_{(1, 20)} = 0.17, p = 0.69
Cg1, 1.54 mm	1.2 ± 0.4	1.7 ± 0.3	1.5 ± 0.4	1.4 ± 0.4	F_{(1, 20)} = 0.61, p = 0.45	14.0 ± 0.5	13.4 ± 0.8	13.3 ± 0.2	14.8 ± 0.5	F_{(1, 20)} = 3.87, p = 0.06
Cg2 , 1.10 mm	1.4 ± 0.2	1.1 ± 0.3	1.9 ± 0.5	1.5 ± 0.3	F_{(1, 20)} = 0.02, p = 0.89	14.1 ± 0.4	14.6 ± 0.5	13.9 ± 0.3	13.7 ± 0.3	F_{(1, 20)} = 0.66, p = 0.43
PrL, 1.98 mm	5.3 ± 0.3	2.9 ± 0.2^##	3.0 ± 0.1^**	2.8 ± 0.2^††	F_{(1, 20)} = 23.04, p < 0.01	15.2 ± 0.5	10.7 ± 0.3^##	10.8 ± 0.3^**	11.2 ± 0.5^††	F_{(1, 20)} = 33.28, p < 0.01
PrL, 1.78 mm	5.5 ± 0.4	2.5 ± 0.1^##	2.9 ± 0.1^**	3.3 ± 0.2^††	F_{(1, 20)} = 46.44, p < 0.01	23.4 ± 1.7	13.5 ± 0.7^##	13.1 ± 1.0^**	13.5 ± 0.5^††	F_{(1, 20)} = 22.12, p < 0.01
PrL, 1.54 mm	2.9 ± 0.4	2.3 ± 0.4	3.0 ± 0.4	2.5 ± 0.5	F_{(1, 20)} = 0.032, p = 0.86	14.2 ± 0.4	14.5 ± 0.7	13.5 ± 0.8	14.6 ± 0.7	F_{(1, 20)} = 0.38, p = 0.54
IL, 1.98 mm	2.1 ± 0.2	4.5 ± 0.2^##	4.4 ± 0.5^**	4.2 ± 0.2^††	F_{(1, 20)} = 17.96, p < 0.01	8.3 ± 0.5	11.7 ± 0.4^##	10.8 ± 0.3^**	11.6 ± 0.3^††	F_{(1, 20)} = 12.43, p = 0.01
IL, 1.78 mm	2.3 ± 0.3	8.4 ± 0.5^##	8.1 ± 0.4^**	8.6 ± 0.7^†	F_{(1, 20)} = 35.35, p < 0.01	8.2 ± 0.5	16.0 ± 0.5^##	16.2 ± 0.6^**	16.0 ± 0.9^††	F_{(1, 20)} = 41.29, p < 0.01
IL, 1.54 mm	2.2 ± 0.3	2.8 ± 0.4	1.8 ± 0.2	2.3 ± 0.3	F_{(1, 20)} = 0.00, p = 1.00	10.6 ± 0.5	11.9 ± 0.3	11.9 ± 0.3	11.8 ± 0.8	F_{(1, 20)} = 1.65, p = 0.21
AI, 1.98 mm	No detectable expression					15.1 ± 1.2	14.0 ± 0.7	14.8 ± 0.3	14.4 ± 0.4	F_{(1, 20)} = 0.30, p = 0.59
AID, 1.78 mm	No detectable expression					11.7 ± 0.4	7.5 ± 0.5^##	6.5 ± 0.4^**	6.2 ± 0.5^††	F_{(1, 20)} = 25.64, p < 0.01
AID, 1.54 mm	No detectable expression					10.5 ± 0.4	7.3 ± 0.3^##	6.4 ± 0.7^**	6.9 ± 0.7^††	F_{(1, 20)} = 12.29, p = 0.02
AIV, 1.78 mm	No detectable expression					14.0 ± 0.9	14.2 ± 0.4	13.5 ± 0.5	13.6 ± 0.6	F_{(1, 20)} = 0.01, p = 0.97
AIV, 1.54 mm	No detectable expression					13.7 ± 0.6	13.7 ± 0.4	11.8 ± 0.6	11.3 ± 0.9	F_{(1, 20)} = 0.22, p = 0.65
PRh, −1.58 mm	No detectable expression					8.4 ± 0.4	8.1 ± 0.2	8.7 ± 0.4	9.3 ± 0.5	F_{(1, 20)} = 1.19, p = 0.29
Ect, −1.58 mm	No detectable expression					18.8 ± 0.6	18.3 ± 0.7	19.3 ± 0.5	19.7 ± 0.8	F_{(1, 20)} = 0.42, p = 0.53
Amygdala nuclei (all −1.58 mm)
Lad	1.7 ± 0.2	1.9 ± 0.3	1.8 ± 0.2	1.6 ± 0.2	F_{(1, 20)} = 0.95, p = 0.341	17.4 ± 0.6	23.2 ± 0.6^##	23.0 ± 0.7^**	23.4 ± 0.3^††	F_{(1, 20)} = 22.50, p < 0.01
Lav	No detectable expression					9.2 ± 0.8	15.9 ± 0.7^##	15.0 ± 1.0^**	14.5 ± 1.1^††	F_{(1, 20)} = 16.05, p < 0.01
BA	3.2 ± 0.3	5.9 ± 0.6^##	5.4 ± 0.2^**	5.8 ± 0.4^††	F_{(1, 20)} = 4.60, p = 0.05	7.3 ± 0.5	10.6 ± 0.7^##	10.4 ± 0.2^**	9.9 ± 0.4^††	F_{(1, 20)} = 14.20, p < 0.01
CeM^a	15.3 ± 1.0	10.4 ± 1.3^##	8.8 ± 1.0^***	10.2 ± 0.9^††	F_{(1, 20)} = 8.47, p = 0.01	71.3 ± 1.7	40.3 ± 3.5^##	38.9 ± 2.1^**	38.2 ± 1.2^††	F_{(1, 20)} = 42.68, p < 0.01
CeL^a	14.6 ± 1.4	15.2 ± 1.4	14.4 ± 1.1	15.6 ± 1.4	F_{(1, 20)} = 0.05, p = 0.83	63.4 ± 2.9	91.3 ± 4.3^##	89.2 ± 3.1^**	94.4 ± 3.3^††	F_{(1, 20)} = 10.66, p < 0.01
CeC^a	9.8 ± 1.4	9.7 ± 1.4	8.8 ± 1.4	8.2 ± 1.2	F_{(1, 20 )}= 0.04, p = 0.84	51.2 ± 1.1	47.2 ± 2.0	45.3 ± 4.1	47.0 ± 2.9	F_{(1, 20)} = 1.06, p = 0.32
Imp^a	No detectable expression					75.8 ± 2.9	41.8 ± 3.3^##	40.0 ± 3.0^**	41.8 ± 2.6^††	F_{(1, 20)} = 36.77, p < 0.01
Ilp^a	No detectable expression					34.5 ± 3.8	33.2 ± 4.8	33.8 ± 3.7	31.7 ± 4.0	F_{(1, 20)} = 0.01, p = 0.92
In^a	No detectable expression					57.7 ± 5.8	93.4 ± 3.1^##	89.3 ± 3.0^**	93.0 ± 2.6^††	F_{(1, 20)} = 17.33, p < 0.01
MePD	4.8 ± 0.5	4.6 ± 0.6	4.5 ± 0.4	4.0 ± 0.6	F_{(1, 20)} = 0.05, p = 0.82	11.3 ± 0.7	12.1 ± 0.4	10.5 ± 0.5	11.0 ± 0.4	F_{(1, 20)} = 0.07, p = 0.79
MePV	8.7 ± 1.0	8.8 ± 0.9	7.2 ± 1.3	7.8 ± 0.6	F_{(1, 20)} = 0.06, p = 0.80	12.8 ± 0.7	13.0 ± 0.4	13.4 ± 0.6	12.5 ± 0.8	F_{(1, 20)} = 0.73, p = 0.40
ACo	8.1 ± 0.9	7.8 ± 1.3	8.0 ± 0.6	7.2 ± 0.9	F_{(1, 20)} = 0.07, p = 0.80	18.6 ± 0.8	18.2 ± 1.6	16.0 ± 1.4	18.8 ± 2.1	F_{(1, 20)} = 1.02, p = 0.32
PLCo	8.0 ± 0.9	7.4 ± 0.8	7.2 ± 0.2	7.7 ± 0.6	F_{(1, 20)} = 0.64, p = 0.43	13.4 ± 1.4	11.8 ± 0.9	12.1 ± 0.7	11.2 ± 1.1	F_{(1, 20)} = 0.08, p = 0.78

^aWhole (sub)nucleus counted.

n = 6 per group.

**p < 0.01, S1 control diet versus B6 control diet;

^##p < 0.01, S1 control diet versus ZnR S1;

^†p < 0.05,

^††p < 0.01, S1 control diet versus ZnR B6.

Bold indicates significant strain–diet ANOVA interactions. Data are mean ± SEM cell numbers. ACo, Anterior cortical; AI, insular cortex; AIV, insular cortex, ventral; CeC, central, capsular; Cg1, cingulate area 1; Cg2, cingulate area 2; Ctl, control diet; Ect, ectorhinal cortex; M1, primary motor; M2, secondary motor; MePD, medial, posterodorsal; MePV, medial, posteroventral; PLCo, posterolateral cortical; PRh, perirhinal cortex.