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. 2011 Jul 1;12(1):9–46. doi: 10.4161/cbt.12.1.15747

Figure 8.

Figure 8

Somatic heterozygous juxtamembrane domain mutation at mRNA position A3316AG, amino acid position R1018G. (A) Mutation position is displayed on exon 13 mRNA position 3,316 (red downward arrow). Indicated change is in the first position of codon AGA (R) to GGA (G) (blue boxes). (B) DYR motif amino acid positions 1,016–1,018 are conserved as depicted here (taken from prophylER analysis). (C) Chromatogram of frozen tissue gastric cancer sample (F6) at genomic position A8415AG, translating into the missense R1018G change.