Table 4.
Hazard Ratios (95% CI) of mobility limitations and mobility disability according to alcohol intake in women (n=1581)
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | ||
|---|---|---|---|---|---|---|
| Events/No | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR 95% CI | HR (95% CI) | |
| Mobility limitations | ||||||
|
| ||||||
| Never/< 1 dr/wk | 538/961 | 1 | 1 | 1 | 1 | 1 |
| Former | 197/299 | 1.22 (1.03–1.43) | 1.18 (0.99–1.39) | 1.15 (0.97–1.36) | 1.15 (0.97–1.36) | 1.10 (0.93–1.31) |
| Light (1 to 3 dr/wk) | 67/146 | 0.78 (0.60–1.00) | 0.84 (0.65–1.09) | 0.80 (0.62–1.04) | 0.86 (0.66–1.12) | 0.89 (0.68–1.15) |
| Moderate (4 to 7 dr/wk) | 42/119 | 0.60 (0.43–0.82) | 0.75 (0.54–1.04) | 0.68 (0.49–0.93) | 0.62 (0.45–0.85) | 0.78 (0.56–1.08) |
| Heavy (> 7 dr/wk) | 24/56 | 0.76 (0.50–1.14) | 0.80 (0.53–1.22) | 0.78 (0.51–1.17) | 0.78 (0.52–1.18) | 0.79 (0.52–1.21) |
|
| ||||||
| Mobility disability | ||||||
|
| ||||||
| Never/< 1 dr/wk | 269/961 | 1 | 1 | 1 | 1 | 1 |
| Former | 103/299 | 1.24 (0.99–1.56) | 1.20 (0.95–1.51 | 1.17 (0.93–1.48) | 1.18 (0.94–1.50) | 1.17 (0.93–1.48) |
| Light (1 to 3 dr/wk) | 23/146 | 0.56 (0.36–0.86) | 0.62 (0.40–0.95) | 0.58 (0.38–0.89) | 0.66 (0.43–1.02) | 0.70 (0.45–1.08) |
| Moderate ( 4 to 7 dr/wk) | 18/119 | 0.58 (0.36–0.93) | 0.73 (0.45–1.20) | 0.65 (0.40–1.05) | 0.61 (0.38–1.00) | 0.79 (0.48–1.29) |
| Heavy (> 7 dr/wk) | 14/56 | 1.01 (0.58–1.73) | 1.07 (0.62–1.85) | 1.10 (0.64–1.89) | 1.07 (0.62–1.86) | 1.15 (0.66–2.01) |
Model 1: adjusted for age, race, site
Model 2: adjusted for age, race, site, and life-style characteristics (education, family income, smoking status, physical activity, BMI)
Model 3: adjusted for age, race, site, and health status-potential confounders (knee osteoarthritis, FEV1/FVC, creatinine clearance, CESD score, and 6-m walk speed)
Model 4: adjusted for age, race, site, and health status-potential mediators (hypertension, prevalent cardiovascular disease, diabetes, ankle brachial index, cognitive impairment, IL-6, incident cardiovascular disease)
Model 5: adjusted for age, race, site, education, family income, smoking status, physical activity, BMI, hypertension, prevalent cardiovascular disease, diabetes, ankle brachial index, knee osteoarthritis, FEV1/FVC, creatinine clearance, cognitive impairment, CESD score, IL-6, incident cardiovascular disease, and 6-m walk speed