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. Author manuscript; available in PMC: 2011 Aug 4.
Published in final edited form as: Curr Drug Targets. 2011 Aug 1;12(9):1284–1290. doi: 10.2174/138945011796150299

Fig. (1). Transcriptional regulation by FOXO3a.

Fig. (1)

FOXO3a modulates proliferation, DNA repair, oxidative stress, apoptosis, metabolism and stem cell maintenance through upregulation of several its downstream targets. For instance, FOXO3a negatively control cell proliferation through transcriptional upregulation of p27KIP1 and promotes cell apoptosis by upregulating pro-apoptotic genes FAS ligand and Bim.