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Summary of Kinase and E3 Ligase Regulate FOXOs and its Effect
| Kinase | FOXO1 | FOXO3 | FOXO4 | FOXO6 | E3 Ligase | Effect |
|---|---|---|---|---|---|---|
| AKT/SGK | T24, S256, S319 | T32, S253, S315 | T28, S193, S258 | T26, S184 | Skp2 (FOXO1) | Inhibition |
| IKKb | S644 | ? | Inhibition | |||
| ERK1/2 | S294, S344, S425 | MDM2 (FOXO3a) | Inhibition | |||
| CK1 | S322, S325 | S318, S321 | S261, S264 | ? | Inhibition | |
| DYRK1A | S329 | S325 | S268 | ? | Inhibition | |
| CDK2 | S249 | ? | Inhibition | |||
| AMPK | T179, S399, S413, S555, S588, S626 | Activation | ||||
| JNK | T447, T451 | Activation | ||||
| MST1 | S207 | Activation |
