Table 4.

Trough plasma concentrations (ng/mL) of sunitinib and total drug (sunitinib plus SU12662) on days 7-28 of sunitinib therapy in 23 children and young adults.

Dose Level			Day 7	Day 14	Day 21	Day 28	Css
15 mg/m2
			N = 14	N = 14	N = 13	N = 11
	Sunitinib	Median	27.8	29.7	37.7	22.5	28.0
		Min	13.4	11.9	8.9	16.1	13.2
		Max	50.4	61.9	64.2	69.7	57.9
	Total Drug	Median	36.9	42.5	43.7	34.9	38.8
		Min	22.0	19.5	10.1	15.6	21.0
		Max	69.7	94.2	90.5	90.5	83.8
	Number with total drug concentration > 50 ng/mL		6	5	6	4	5
20 mg/m2			N = 9	N = 8	N = 8	N = 7
	Sunitinib	Median	35.9	31.0	37.4	46.7	36.5
		Min	23.1	26.9	24.2	23.4	28.2
		Max	55.1	58.6	62.9	86.2	65.0
	Total Drug	Median	48.2	45.4	49.3	66	50.6
		Min	32.8	39.2	41.1	34.5	43.2
		Max	83.2	90.5	104.7	147.3	106.4
	Number with total drug concentration > 50 ng/mL		4	2	4	6	5

Absolute doses received per assigned dose level: 15 mg/m² dose level - 12.5 mg (n = 4), 25 mg (n = 10); 20 mg/m² dose level - 12.5 mg (n = 1), 25 mg (n = 7), 37.5 mg (n = 1).