Table 1.

Conventional prognostic factors in stage III non-small cell lung cancer: surgical series.

Study	Year	ISS	Stage	N patients	Treatment	Significant factors in multivariate analysis
Vansteenkiste et al. [1997]	1997	4th?	IIIAN2	140	Surgery	T, PS, n N stations, histology, cN2
Suzuki et al. [1999a]	1999	5th	pN2	222	Surgery	cN, T size, n N2 stations, R0
Andre et al. [2000]	2000	5th	III	702	Surgery	pT, N2, induction CT
Choi et al. [2002]	2002	4th	pN2	101	Surgery + other	RO, CT use
Kameyama et al. [2002]	2002	5th	III	152	Surgery	Age, R0, pN
Osaki et al. [2003]	2003	5th	T4N0-2	76	Surgery	pN, R0
Lorent et al. [2004]	2004	?	IIIApN2	131	CT → surgery (or RT)	pT, mediastinal downstaging
Niizeki et al. [2004]	2004	5th	cN2-pN0	45	Surgery	Visceral pleural invasion, CEA level
Tanaka et al. [2004]	2004	5th	pIIIAN2	99	Surgery → CT or RT	cN2, n N2 stations, MCV (CD105), PI
Barlesi et al. [2005]	2005	5th	IIIAN2/IIIB	95/60	CT → surgery	IIIA: mediastinal downstaging, post-operative complication
						IIIB: vascular invasion
Betticher et al. [2006]	2006	5th	IIIApN2	75	CT → surgery	R0, pathological response, mediastinal downstaging
Tomita et al. [2006]	2006	?	pN2	78	Surgery	None
Garrido et al. [2007]	2007	?	IIIAN2/IIIB	136	CT → surgery	R0, response to induction CT, age
Kim et al. [2007]	2007	?	IIIAN2	66	CRT → surgery	ypN
Riquet et al. [2007]	2007	5th	pN2	586	Surgery	Age, pT, one N2 station, adjuvant treatment
Van Meerbeeck et al. [2007]	2007	5th	IIIAN2	332	CT → surgery or RT	Histology
Kim et al. [2008]	2008	5th	IIIAN2/dry IIIB	42	CT → surgery	Downstaging
Lee et al. [2008]	2008	5th	IIIAN2	262	Surgery +/− CRT	Age, adjuvant CT, n N2 stations
Caglar et al. [2009]	2009	?	III	144	CRT +/− surgery	Stage, surgery
Albain et al. [2009]	2009	?	IIIAN2	396	CRT +/− surgery	Weight loss, gender, nN2 stations

ISS, International Staging System; PS, performance status; R0, complete resection; CT, chemotherapy; CRT, radiochemotherapy; CEA, carcinoembryonic antigen; MCV, microvessel density; PI, proliferative index.