Table 2.

Hepatocyte growth factor receptor (HGFR) is a target of mutations in various malignancies. Known mutations within the semaphorin (SEMA), immunoglobulin plexin transcription (IPT), juxtamembrane (JM), and tyrosine kinase (TK) domain of MET are summarized. Mutations were found in non-small cell lung cancer (NSCLC), small-cell lung cancer (SCLC), mesothelioma, head and neck squamous cell carcinoma (HNSCC), melanoma, glioma, breast cancer, gastric cancer, and renal cell carcinoma in somatic (green) or germ line (orange) cells. There are two isoforms of HGFR and the amino acids are numbered according to the canonical isoform 1. The sequence of isoform 2 was used in some publications (differences indicated in brackets) and contains the following sequence after S755: TWWKEPLNIVSFLFCFAS (see also http://www.uniprot.org and [Krishnaswamy et al. 2009]). Hepato, hepatocellular carcinoma. *Tissue not indicated in publication.