. 2011 Jul;3(4):207–218. doi: 10.1177/1758834011409000

Table 3.

Pemetrexed and non-small cell lung cancer histology: squamous versus adenocarcinoma, large-cell carcinoma and not other specified types. Data shown as hazard ratio. Data from Scagliotti et al., [2008] and Ciuleanu et al., [2009].

Histology	1^st line: Cis-Pem vs. Cis-Gem	2^nd line: Pern vs. Doc	Maintenance: Pern vs. Plac
Non-squamous	0.81^*	0.78^*	0.70^*
Adenocarcinoma	0.84^*	0.92	0.73^*
Large cell	0.67	0.27^*	0.98
NOS	1.08	0.57	0.61^*
Squamous	1.23	1.56^*	1.07

Cis-Gem, cisplatin plus gemcitabine; Doc, docetaxel; Pem, pemetrexed; Plac, placebo; NOS, not otherwise specified; *p < 0.05