Table 1.
Selected studies showing independent predictors for 5-year cancer-specific survival (CSS) after treatment of upper urinary tract urothelial carcinoma (UTUC) with radical nephroureterectomy (RNU).
| Study | Number of patients (mean age years) | Independent predictors on multivariate analyses | [Hazard ratio] | 5-year CSS | Mean follow up (months) |
|---|---|---|---|---|---|
| [Novara et al. 2007] (multicentre, 3 centres) | 269 (68) | Prior bladder cancer | [1.743] | 76% | 34 |
| Prior muscle-invasive bladder cancer | [4.687] | ||||
| Multifocality | [2.971] | ||||
| Pathologic stage | [3.346] | ||||
| N-Stage | [2.978] | ||||
| [Margulis et al. 2009] (multicentre, 12 centres) | 1363 (70) | Stage T2 | [2.811] | 73% | 51 |
| T3 | [5.168] | ||||
| T4 | [11.04] | ||||
| N-Stage | [1.713] | ||||
| Grade (high versus low) | [1.745] | ||||
| Lymphovascular invasion | [1.370] | ||||
| Tumour architecture papillary/sessile | [1.532] | ||||
| [Li et al. 2009] (single centre) | 145 (65) | Stage T3 | [9.479] | 75% | — |
| T4 | [62.79] | ||||
| Severe chronic kidney disease | [7.089] |