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. 2011 May 11;2:15. doi: 10.3389/fimmu.2011.00015

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Copyright © 2011 Rucci, Poliani, Caraffi, Paganini, Fontana, Giliani, Alt and Notarangelo.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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Altered maturation of CD4⁺ SP medullary thymocytes in the lig4^R/R and rag1^S/S mice. Upper panels: Representative FACS plots of CD4⁺ SP medullary thymocytes at various stages of maturation according to the expression of CD69 and Qa2 surface markers. Lower panels: Distribution of the different populations of SP1–SP4 cells. lig4^R/R and rag1^S/S mice have a significant accumulation of SP4 thymocytes. Mean values ± SE are shown. At least six mice per group were analyzed.