Table 3. Distributions of genotypes of IL-4, IL-4R and IL-13 their associations with risk of CWP.

Variables	CWP cases		Controls		P a	OR (95% CI)	OR (95% CI)b
	N	%	N	%
IL4 C-590T	n = 553		n = 541
TT	369	66.7	323	59.7	0.049	1.00	1.00
CT	162	29.3	195	36.0		0.72 (0.56–0.93)	0.71 (0.55–0.92)
CC	22	4.0	23	4.3		0.83 (0.45–1.52)	0.85 (0.46–1.53)
CT/CC	184	33.3	218	40.3	0.016	0.74 (0.58–0.95)	0.73 (0.57–0.94)
T allele	900	81.4	841	77.7	0.034	1.00
C allele	206	18.6	241	22.3		0.80 (0.65–0.98)
IL4R Ile50Val	n = 556		n = 539
CC	145	26.1	138	25.6	0.512	1.00	1.00
CT	286	51.4	264	49.0		1.05 (0.79–1.39)	1.06 (0.80–1.42)
TT	125	22.5	137	25.4		0.88 (0.63–1.23)	0.89 (0.64–1.25)
C allele	576	51.8	540	50.0	0.425	1.00
T allele	536	48.2	538	50.0		0.93 (0.79–1.10)
IL4R Ser478Pro	n = 554		n = 538
TT	468	84.5	445	82.7	0.141	1.00	1.00
CT	83	15.0	93	17.3		0.85 (0.62–1.18)	0.83 (0.60–1.15)
CC	3	0.5	0	0.0		-	-
T allele	1019	92.0	983	91.4	0.606	1.00
C allele	89	8.0	93	8.6		0.92 (0.68–1.25)
IL4R Gln551Arg	n = 553		n = 534
AA	393	71.1	372	69.7	0.756	1.00	1.00
AG	147	26.6	146	27.3		0.96 (0.74–1.26)	0.96 (0.73–1.25)
GG	13	2.3	16	3.0		0.78 (0.37–1.64)	0.78 (0.37–1.66)
A allele	933	84.4	890	83.3	0.516	1.00
G allele	173	15.6	178	16.7		0.93 (0.74–1.17)
IL13 C-1055T	n = 552		n = 538
CC	396	71.7	376	69.9	0.643	1.00	1.00
CT	137	24.8	146	27.1		0.89 (0.68–1.17)	0.90 (0.68–1.18)
TT	19	3.4	16	3.0		1.13 (0.57–2.22)	1.12 (0.57–2.22)
C allele	929	84.1	898	83.5	0.661	1.00
T allele	175	15.9	178	16.5		0.95 (0.76–1.19)
IL13 Arg130Gln	n = 554		n = 539
GG	294	53.1	255	47.3	0.131	1.00	1.00
AG	219	39.5	245	45.5		0.78 (0.61–0.99)	0.80 (0.62–1.02)
AA	41	7.4	39	7.2		0.91 (0.57–1.46)	0.94 (0.58–1.50)
G allele	807	72.8	755	70.0	0.148	1.00
A allele	301	27.2	323	30.0		0.87 (0.72–1.05)

^aTwo-sided χ² test.

^bAdjusted for age, exposure years, pack-years of smoking, and job type.