Table 5. Frequency distributions of the combined genotypes of IL-4, IL-4R and IL-13 between CWP cases and controls.
No. of risk allelesa | Cases | Controls | OR (95%CI)b | P | ||
No. | % | No. | % | |||
0–8 | 151 | 27.8 | 178 | 33.7 | 1.00 | |
9 | 117 | 21.5 | 112 | 21.2 | 1.25 (0.89–1.74) | 0.196 |
10 | 147 | 27.0 | 136 | 25.8 | 1.28 (0.93–1.76) | 0.125 |
11–12 | 129 | 23.7 | 102 | 19.3 | 1.47 (1.05–2.05) | 0.025 |
P trend | 0.023 |
Risk alleles included IL-4 rs2243250 T, IL-4R rs1805010 C, IL-4R rs1805015 T, IL-4R rs1801275 A, IL-13 rs1800925 C, and IL-13 rs20541 G alleles.
Adjusted for age, exposure years, pack-years of smoking, and job type.