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. Author manuscript; available in PMC: 2011 Aug 4.
Published in final edited form as: Nat Immunol. 2010 Jul 11;11(8):751–758. doi: 10.1038/ni.1904

Figure 1.

Figure 1

Inhibition by 5-lipoxygenase of the early initiation of an immune response after M. tuberculosis infection. (a,b) Frequency of TB10.4(4–11)-specific CD8+ T cells in the thoracic draining lymph nodes (a) and lungs (b) of Ptges−/−, wild-type (WT) and Alox5−/− mice 2 weeks after M. tuberculosis infection. Numbers adjacent to outlined areas indicate percent CD8+ T cells stained with the TB10.4(4–11)-loaded H-2Kb tetramer (H-2Kb–TB10.4(4–11)). Data are representative of two independent experiments (mean of four to five mice per group). (c) Kinetics of the pulmonary TB10.4-specific CD8+ T cell response in Ptges−/−, wild-type and Alox5−/− mice. *P < 0.05 (one-way analysis of variance (ANOVA)). Data are representative of two experiments (mean ± s.e.m. of four mice per group).