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. Author manuscript; available in PMC: 2011 Aug 4.
Published in final edited form as: Nat Immunol. 2010 Jul 11;11(8):751–758. doi: 10.1038/ni.1904

Figure 3.

Figure 3

Transfer of infected Alox5−/− alveolar macrophages generates pulmonary and systemic CD4+ and CD8+ T cell responses. (a) Frequency of TB10.4(4–11)-specific CD8+ T cells in the lungs, PLN and spleen 17 d after intratracheal transfer of alveolar macrophages (MΦ) from wild-type mice (left) or Alox5−/− mice (right) infected by aerosol with M. tuberculosis (virulent Erdman strain). Numbers adjacent to outlined areas indicate percent CD8+ T cells stained with H-2Kb–TB10.4(4–11) or streptavidin-phycoerythrin alone (Control; bottom row). Data are from one experiment. (b) Frequency of H-2Kb–TB10.4(4–11)–stained CD8+ T cells in the lungs, PLN and spleens of mice treated as described in a (n = 5 per group). Staining with isotype-matched control antibody (Isotype) is shown for the wild-type group only. *P < 0.05 (one-way ANOVA with the Bonferroni post-test). Data are from one experiment (mean and s.e.m.).