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. Author manuscript; available in PMC: 2012 Jan 8.
Published in final edited form as: Science. 2011 Jun 2;333(6039):186. doi: 10.1126/science.1206593

Figure 1. Adult deletion of Mecp2 recapitulates germline knock-out.

Figure 1

(A–B) MeCP2 is depleted in adult knock-out (AKO) mice by western blot of brain lysates (A, N= 3–4 mice per genotype), and by immunofluorescence in cerebellum (B). Scale bar = 50um. (C) AKO mice display symptoms of disease. N= 6–12 per genotype. (D) AKO mice develop motor and learning impairments similar to germline Mecp2null/y (KO) mice. N=10–26 per genotype. (E) Sst and Grin2a mRNA levels are altered in AKO mice. N = 4–12 per genotype. (F) AKO mice die prematurely (left) similar to KO mice (right). N=10–26 per genotype. Data presented as mean ± s.e.m. (*) p<0.05, (**) p<0.01, or (***) p<0.001.