Table 4.
Effects of Seizures on CCCs.
| Model | Species | Age at seizures | Region | Effects | Ref. |
|---|---|---|---|---|---|
| Ictal changes | |||||
|
| |||||
| Kainic acid | Rat | PN6-7 | Hippocampus | Switch from hyperpolarizing to depolarizing EGABA | [184] |
| Low Mg2+ seizures | Mice | PN5 | Hippocampus | Bumetanide sensitive increase in [Cl−]i | [150] |
|
| |||||
| After seizures | |||||
|
| |||||
| Kainic acid | Rat (male) | PN4-6 | Hippocampus (at least 4 days postictally) | Increased KCC2; decreased NKCC1 activity; more hyperpolarizing EGABA | [185] |
| Kainic acid | Rat (female) | PN4-6 | Hippocampus (at least 4 days postictally) | No change in KCC2; increased NKCC1 activity; more depolarizing EGABA | [185] |
| Kainic acid | Rat (male) | PN5-7 | Hippocampus (immediate postictal period) | Increased surface expression of KCC2; hyperpolarizing shift of EGABA | [171] |