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. 2011 Jul 19;3:197–206. doi: 10.2147/IJWH.S13427

Table 2.

Treatment recommendations for pelvic inflammatory disease1

Route of administration Antimicrobial regimen
Parenteral component2 Oral component
Parenteral + oral Regimen A Cefotetan 2 g IV every 12 hours Doxycycline 100 mg orally twice a day to complete a 14-day course PLUS, when tubo-ovarian abscess is present,
OR PLUS
Cefoxitin 2 g IV every 6 hours
PLUS
Doxycycline 100 mg orally or IV every 12 hours
Regimen B Clindamycin 900 mg IV every 8 hours PLUS Clindamycin 450 mg orally four times a day to complete a 14-day course
PLUS
Gentamicin loading dose 2 mg/kg IV or IM, followed by a maintenance dose of 1.5 mg/kg every 8 hours. Single daily dosing (3–5 mg/kg) can be substituted OR
Alternative Ampicillin/Sulbactam 3 g IV every 6 hours
PLUS PLUS Metronidazole 500 mg orally two times a day tocomplete a 14-day course
Doxycycline 100 mg orally or IV every 12 hours
Oral Recommended Ceftriaxone 250 mg IM in a single dose
OR
Cefoxitin 2 g IM in a single dose and Probenecid, 1 g orally administered concurrently in a single dose
OR
Other parenteral third-generation cephalosporin
(eg, ceftizoxime or cefotaxime)
PLUS
Doxycycline 100 mg orally twice a day for 14 days
WITH or WITHOUT
Metronidazole 500 mg orally twice a day for 14 days
Alternative Ceftriaxone 250 mg IM in a single dose
PLUS
Azithromycin 1 g orally once a week for two weeks
WITH or WITHOUT
Metronidazole 500 mg orally twice a day for 14 days

Notes:

1

Adapted from the 2010 CDC STD treatment guidelines;35

2

Parenteral treatment should be continued until 24 hours following the improvement of clinical symptoms.