Table I.
Rate of FNB anti-CD3 mAb depletion of naïve and Th1 effector CD4 cells in vivo1
| Rate of depletion (%) | ||
|---|---|---|
| Endogenous naïve CD4 |
Transferred Th1 | |
| Exp1 | 36.8 | 65.5 |
| Exp2 | 36.8 | 66.3 |
| Exp3 | 12.1 | 40.0 |
| Exp4 | 35.5 | 66.4 |
1
Th1 cell clones were differentiated as described in the materials and methods section and transferred to lympho-replete hosts that were then treated with FNB anti-CD3. The rate of depletion was calculated by comparing the percent of endogenous naïve (CD4+CD62L+CD25) and transferred cells in spleens of control vs treated mice.