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. Author manuscript; available in PMC: 2012 Aug 2.
Published in final edited form as: Circulation. 2011 Jul 18;124(5):582–588. doi: 10.1161/CIRCULATIONAHA.111.031716

Figure 5.

Figure 5

ERTR7 immunolocalization (red) in heart sections shows that the mononuclear cell infiltrate (nuclei stained blue) in damaged regions of het-untreated cardiac muscle is mostly composed of fibroblasts. The less frequent areas of damage in the het-treated-8 group still contain fibroblasts, suggesting that the drug treatment is not acting directly on fibroblast proliferation or migration. Since very few areas of cardiac damage are present in het-treated-4 hearts, clusters of activiated fibroblasts are not typically present.