Table 2.
Synthesis of N-substituted isatin derivatives
| Compound | R | Time (h) | Yield (%) |
|---|---|---|---|
| 1 | H | _ | _ |
| 2 | CH3 | 4 | 87 |
| 3 | C2H5 | 12 | 89 |
| 4 | (CH2)2CH3 | 12 | 89 |
| 5 | (CH2)3CH3 | 24 | 93 |
| 6 | (CH2)4CH3 | 24 | 90 |
| 7 | (CH2)5CH3 | 24 | 95 |
| 8 | CH2CH = CH2 | 12 | 93 |
| 9 | CH2C6H5 | 12 | 90 |
| 10 | CH2COOC2H5 | 12 | 93 |
| 11 | C2H4Cl | 24 | 79 |
| 12 | C2H4Br | 24 | 83 |