Table 5.
Effect of Each Initial Treatment Course on Renal Function
| Indomethacin | Ibuprofen | Comparison between treatments on changes from baseline (ANOVA) | ||||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 1st course | p value for change with indomethacin (t-test) | Baseline | 1st course | p value for change with ibuprofen (t-test) | p value for main treatment effect | p value for treatment - time interaction | |
| Urine output (mL/kg/hr; mean ± SD) | 3.9 ± 1.4 | 3.6 ± 1.4 | 0.033 * | 4.2 ± 1.6 | 4.0 ± 1.4 | 0.24 | 0.51 | 0.50 |
| Serum Creatinine (mg/dL; mean + SD) | 0.96 ± 0.21 | 1.06 ± 0.24 | <0.001* | 0.93 ± 0.2 | 0.98 ± 0.24 | 0.005 * | 0.039* | 0.047 * |
Supplemental analyses of the effect of each initial treatment course on renal function.
* denotes statistically significant (p < 0.05) change from baseline within a treatment group